2016 Accepted
Ellmark P, Mangsbo SM, Lindstedt M.
Selective FcγR engagement by human agonistic anti-CD40 antibodies. Accepted 2016, Translational Cancer Research (commentary).

van Hooren L, Sandin LC, Moskalev I, Ellmark P, Dimberg A, Black P, Tötterman TH, Mangsbo SM.
Local checkpoint inhibition of CTLA-4 prevents the growth of experimental bladder cancer in mice. Accepted 2016, Eur J Immunol .

Arts RJW, Plantinga TS, Tuit S, Ulas T, Heinhuis B, Tesselaar M,  Sloot Y, Adema GJ, Joosten LAB, Smit JWA, Netea MG, Schultze JL, Netea-Maier RT.
Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages. Oncoimmunology, Sept 2016. Online access: http://dx.doi.org/10.1080/2162402X.2016.1229725

Castellano E, Molina-Arcas M, Krygowska AA, East P, Warne P, Nicol A, Downward J.
RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression. Nat Commun, 7: 11245, 2016.

Coffelt SB, Wellenstein MD, de Visser KE.
Neutrophils in cancer: neutral no more. Nat Rev Cancer, 16: 431-446, 2016.

Hooren LV, Georganaki M, Huang H, Mangsbo SM, Dimberg A.
Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment. Oncotarget, 31 ( Jul 1), 2016. [Epub ahead of print]

Salvagno C, de Visser KE.
Purification of Immune Cell Populations from Freshly Isolated Murine Tumors and Organs by Consecutive Magnetic Cell Sorting and Multi-parameter Flow Cytometry-Based Sorting. Methods Mol Biol, 1458: 125-135, 2016.

Schmidt SV, Krebs W, Ulas T, Xue J, Baßler K, Günther P, Hardt AL, Schultze H, Sander J, Klee K, Theis H, Kraut M, Beyer M, Schultze JL.
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin. Cell Res, 26: 151-770, 2016.

Coffelt SB, de Visser KE.
Immune-mediated mechanisms influencing the efficacy of anticancer therapies. Trends Immunol, 36: 198-216, 2015.

Fassl SK, Austermann J, Papantonopoulou O, Riemenschneider M, Xue J, Bertheloot D, Freise N, Spiekermann C, Witten A, Viemann D, Kirschnek S, Stoll M, Latz E, Schultze JL, Roth J, Vogl T.
Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8. J Immunol 194: 575-583, 2015.

Huang H, Langenkamp E, Georganaki M, Loskog A, Fuchs PF, Dieterich LC, Kreuger J, Dimberg A.
VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation. FASEB J, 29: 227-238, 2015.

Kersten K, Salvagno C, de Visser KE.
Exploiting the immunomodulatory properties of chemotherapeutic drugs to improve the success of cancer immunotherapy. Front Immunol, 6: 516, 2015.

Schultze JL.
Reprogramming of macrophages — new opportunities for therapeutic targeting. Curr Opin Pharmacol, 25: 10-15, 2015.

Krebs W, Schmidt SV, Goren A, De Nardo D, Labzin L, Bovier A, Ulas T, Theis H, Kraut M, Latz E, Beyer M, Schultze JL.
Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Res 42: 13051-13060, 2014.

Liljenfeldt L, Yu D, Chen L, Essand M, Mangsbo SM.
A hexon and fiber-modified adenovirus expressing CD40L improves the antigen presentation capacity of dendritic cells. J Immunother 37: 155-162, 2014.

Sandin LC, Eriksson F, Ellmark P, Loskog ASI, Tötterman TH, Mangsbo SM.
Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo. Onco Immunol 3: 1-8, 2014.

Sandin LC,  Orlova A,  Gustafsson E, Ellmark P, Tolmachev V,  Tötterman TH, Mangsbo SM.
Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer. Cancer Immunol Res 2: 80-90, 2014.

Schmidt SV,  Schultze JL.
New insights into IDO biology in bacterial and viral infections. Front Immunol 5: 1-12, 2014.

Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Ganesan H, Nino-Castro A, Mallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL.
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40: 274-288, 2014.



The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7/2007-2013 under REA grant agreement no. 317445